Mounjaro Outperforms Wegovy in Major Weight-Loss Drug Trial

Mounjaro is a new medication developed by Eli Lilly that contains the active ingredient tirzepatide. It was originally designed to help people with type 2 diabetes manage their blood sugar levels. Mounjaro is administered as a once-weekly injection using a self-injection pen, typically into the abdomen, thigh, or upper arm. In the UK, tirzepatide (Mounjaro) has been approved for use by the Medicines and Healthcare products Regulatory Agency (MHRA).

Besides helping with blood sugar, Mounjaro has also been found to be very effective at helping people lose weight. This is why you might have heard it called a "weight loss jab" in the media.

• How you take it: You inject Mounjaro once a week. Your doctor will usually start you on a small dose and slowly increase it over time. This helps your body get used to the medicine and can lower the chance of you feeling sick.

How it Works:

Mounjaro is like a "twin hormone" medicine. It acts like two natural gut hormones, GLP-1 and GIP. These hormones help control blood sugar and appetite.

• It helps your body release more insulin when needed and lowers sugar from your liver, improving blood sugar control.
• It makes you feel fuller sooner and for longer, helping you eat less.
• Working on both GLP-1 and GIP is thought to be why it can lead to greater weight loss than medicines that only use GLP-1 (like Semaglutide in Ozempic/Wegovy).

What is it Used For?

1. Type 2 Diabetes: Mounjaro lowers blood sugar effectively, often helping patients reach better levels (lower HbA1c). It's used alongside diet and exercise, sometimes with other diabetes medicines, typically when standard treatments aren't enough, especially if weight loss would help.
2. Weight Management: In studies, people using Mounjaro lost a significant amount of weight, often averaging 15-20% of their body weight over about 1 to 1.5 years. It's approved for adults with obesity (high BMI) or those with a lower BMI and a weight-related health problem.

Access in the UK:

• NHS: Mounjaro is available on the NHS for type 2 diabetes if you meet certain criteria. For weight loss, NHS access is starting gradually through specialist clinics for adults with a very high BMI and multiple weight related health issues.
• Private: You can also access Mounjaro privately through weight loss clinics, pharmacies or online services like ours if you meet the medical criteria. SheMed operates a weight management programme specifically tailored for women, which includes the potential prescription of GLP-1 medications such as Mounjaro and Wegovy, provided the individual meets their medical criteria.

Mounjaro vs. Semaglutide (Ozempic/Wegovy):

Both are effective weekly injections. Semaglutide works on GLP-1 while Mounjaro works on both GLP-1 and GIP. Studies suggest Mounjaro may lead to slightly more weight loss on average. But choice of drug depends on a number of factors and is very individual.

Side Effects and Safety:

Common side effects are usually mild stomach issues (nausea, vomiting, etc.) that often improve over time. Because it affects appetite, you'll feel less hungry. If you take other diabetes medicines, your doctor might adjust doses to prevent low blood sugar.

Serious side effects are rare, but contact a doctor immediately for severe tummy pain, persistent vomiting, allergic reactions, or worrying mood changes.

Important Note: Mounjaro works best with healthy eating and exercise. If you stop Mounjaro, appetite and weight can return if lifestyle changes aren't maintained.

Check our healthcare support page to see if Mounjaro could be a suitable option for you based on your health needs and the latest criteria.

FAQs 

1. How is Mounjaro administered?
Mounjaro is given as a once-weekly injection. Your healthcare provider will guide you on the correct dosage and administration technique.

2. Can I use Mounjaro if I’m pregnant or breastfeeding?
No, tirzepatide is not recommended during pregnancy or breastfeeding, as its safety in these situations has not been established. If you are planning to conceive or are breastfeeding, discuss alternative options with your doctor.

3. How long does it take to see results with Mounjaro?
While individual results vary, many users begin noticing changes within a few weeks. Maximum benefits are typically observed after several months of consistent use, alongside dietary and lifestyle adjustments.

References

1. MotherToBaby. (2024). Tirzepatide (Mounjaro®, Zepbound®) - Mother To Baby | Fact Sheets. https://www.ncbi.nlm.nih.gov/books/NBK605070/
2. Watanabe, M., & Hasegawa, Y. (2021). Tirzepatide in adults with obesity and type 2 diabetes. New England Journal of Medicine, 385(11), 1046-1056. https://doi.org/10.1056/NEJMoa2107519
3. Kahn, S. E., & Florez, J. C. (2023). Tirzepatide: A dual GLP-1 and GIP receptor agonist for type 2 diabetes management. PMC, 11543192. https://pmc.ncbi.nlm.nih.gov/articles/PMC11543192/
4. Kahn, S. E., & Florez, J. C. (2023). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine. https://pubmed.ncbi.nlm.nih.gov/36751934/
5. Nauck, M. A., & Quast, D. R. (2020). Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide: A review of their roles in obesity and type 2 diabetes. Endocrine Reviews, 41(3), 1-24. https://pubmed.ncbi.nlm.nih.gov/32459834/‍
6. Kahn, S. E., & Florez, J. C. (2020). Tirzepatide: A novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist for type 2 diabetes management. Endocrine Society. https://www.ncbi.nlm.nih.gov/books/NBK605070/

Many individuals find themselves in a constant battle with their weight, despite maintaining active lifestyles and trying various diets and exercise routines. Stubborn pounds can feel impossible to lose, leading to feelings of frustration and defeat. If you've experienced the seemingly endless cycle of trying to shed weight without lasting success, you understand this challenge. However, recent advancements offer a potential breakthrough. GLP-1 medications, a class of drugs that mimic natural hormones to help regulate hunger and insulin, have shown promising results for weight loss. When combined with healthy lifestyle changes – including a balanced diet, regular physical activity, sufficient sleep, and stress management – these medications can create a powerful synergistic effect, not only aiding in weight loss but also supporting overall metabolic health.

Mechanism of Action: How GLP-1 Agonists Help with Weight Loss

GLP-1 receptor agonists work by mimicking a natural hormone in your body that helps regulate appetite, insulin, and digestion. When you take a GLP-1 medication like Mounjaro, Wegovy, or Ozempic, it activates GLP-1 receptors in the brain and gut. This leads to three main effects that support weight loss:

• Reduced Appetite: GLP-1 agonists signal to your brain that you’re full, even after smaller meals. This makes it easier to stick to a calorie-controlled diet.
  
  
• Slower Digestion: These medications delay gastric emptying, which means food stays in your stomach longer, helping you feel full for longer periods.
  
  
• Improved Blood Sugar Control: By increasing insulin secretion and reducing glucagon release when needed, GLP-1 drugs help maintain stable blood sugar levels — which is especially helpful for people with type 2 diabetes.
  

By targeting both biological and behavioural aspects of eating, GLP-1 medications make it easier to create a calorie deficit — the foundation of sustainable weight loss.

NHS and Private Use Guidelines for GLP-1 Medications

GLP-1 medications such as Wegovy and Mounjaro are approved for weight management when used alongside lifestyle changes like a reduced-calorie diet and regular exercise.

• On the NHS, GLP-1s are typically prescribed to adults with:
  
  
  • A BMI of 35 or more (lower for some ethnic groups)
    
  • At least one weight-related condition (e.g. type 2 diabetes, high blood pressure)
    
    
• In private care, GLP-1 medications may be considered for patients who meet clinical eligibility — typically starting at a BMI of 30 or above, or 27 with weight-related health conditions, as per regulatory guidance. At SheMed Healthcare, every patient undergoes a clinical assessment and blood test to confirm suitability before treatment begins.

Whether prescribed via the NHS or privately, GLP-1 medications should always be part of a structured, long-term weight management plan, not used in isolation.

The Role of Lifestyle Changes in Maximising Weight Loss with GLP-1 Therapy

Diet: The Foundation of Effective Weight Loss

A balanced diet is a cornerstone of any weight loss journey, and it's particularly important when combining it with GLP-1 therapy. GLP-1 medications can help reduce appetite and regulate blood sugar levels, but diet plays a crucial role in achieving and maintaining weight loss.

1. Importance of a Balanced Diet

A well-rounded, nutrient-dense diet is essential for weight loss and long-term health. Research shows that diets rich in whole foods, fibre, and lean proteins, while limiting processed sugars and unhealthy fats, can aid in sustainable weight management.

In the Diabetes Prevention Program (DPP), participants who combined a low-calorie, low-fat diet with physical activity and behavioural counselling were able to lose 5-7% of their body weight, significantly reducing their risk of developing type 2 diabetes. This highlights the importance of diet in weight management, especially when combined with GLP-1 therapy.

2. Caloric Restriction

GLP-1 medications naturally help with appetite suppression, but pairing them with caloric restriction such as reducing intake by 500–750 calories per day can accelerate weight loss. Clinical studies suggest that even modest reductions in caloric intake lead to significant weight loss over time. The STEP 1 Trial demonstrated that semaglutide (a GLP-1 medication) combined with caloric restriction resulted in a 15% average weight loss over 68 weeks.

3. Macronutrient Balance (Protein, Carbohydrates, Fats)

A balanced intake of macronutrients is key to supporting energy levels and maintaining muscle mass while losing fat. Protein is particularly important for preserving lean mass during weight loss.

• Protein: Aim for 20-30% of daily calories from protein sources like lean meats, legumes, and tofu. This helps keep you feeling full and prevents muscle loss.
• Carbohydrates: Focus on complex carbohydrates (whole grains, vegetables) to provide sustained energy and fibre.
• Fats: Include healthy fats from sources like olive oil, nuts, and seeds, which support hormonal balance and promote satiety.

4. Mindful Eating Practices

Mindful eating helps women tune into their hunger cues and reduce overeating. Studies show that mindfulness can reduce emotional eating and improve long-term weight management. A meta-analysis found that mindfulness-based interventions improved weight loss outcomes and sustained weight maintenance in participants over a year.

Physical Activity: Moving for Metabolic Health

Physical activity is vital for supporting the effects of GLP-1 therapy and enhancing weight loss. Regular exercise not only helps burn calories but also improves insulin sensitivity, supports cardiovascular health, and boosts mental well-being.

1. Regular Exercise Recommendations

The government recommends that adults engage in at least 150 minutes of moderate-intensity aerobic activity (e.g., brisk walking, cycling) or 75 minutes of vigorous-intensity aerobic activity (e.g., running, swimming) each week, in addition to strength training exercises twice a week. In the DPP trial, participants who engaged in physical activity and dietary changes lost an average of 7% of their body weight, while also improving their insulin sensitivity.

2. Types of Physical Activity

Combining different types of exercise maximises benefits:

• Cardiovascular Exercise: Activities like walking, running, cycling, or swimming improve heart health, burn calories, and increase fat oxidation.
• Strength Training: Incorporating strength training (e.g., weightlifting, bodyweight exercises) helps build muscle mass, which increases metabolism and supports fat loss. A study found that combining aerobic exercise with strength training led to significantly greater fat loss than either alone.

3. Incorporating Exercise into Daily Routine

Starting small and gradually increasing exercise intensity is key to building consistency. Here are a few tips:

• Start with short, manageable sessions (e.g., 15–20 minutes) and gradually increase as your fitness level improves.
• Incorporate physical activity into daily routines, such as walking or cycling to work, taking the stairs instead of the lift, or engaging in home workouts.

Sleep: Restoring Balance for Weight Regulation

Sleep is a powerful yet often overlooked aspect of weight management. Quality sleep is essential for hormonal regulation, appetite control, and energy balance.

1. Importance of Quality Sleep

Chronic sleep deprivation can disrupt hormones like ghrelin (hunger hormone) and leptin (satiety hormone), leading to increased appetite and cravings for unhealthy foods. Women, particularly during perimenopause and menopause, often experience disrupted sleep patterns, which can make weight loss more challenging. A study showed that people who slept less than 7 hours per night had higher levels of ghrelin and lower levels of leptin, which can contribute to weight gain.

2. Sleep Hygiene Tips

• Stick to a regular sleep schedule, going to bed and waking up at the same time every day.
• Create a relaxing bedtime routine, such as reading or listening to calming music.
• Avoid heavy meals, caffeine, and screens at least an hour before bed.

3. Impact of Sleep on Weight Regulation

A study from The Sleep Research Society found that women who consistently get 7-9 hours of sleep per night are more likely to maintain a healthy weight compared to those who sleep less.

Stress Management: Balancing the Mind and Body

Stress can have a profound impact on weight loss. High stress levels can trigger the release of cortisol, a hormone that promotes fat storage, especially in the abdominal area. Managing stress is therefore crucial for successful weight loss.

Techniques for Stress Reduction

Incorporating stress management practices can improve overall well-being and support weight loss:

• Meditation: Practising mindfulness meditation reduces cortisol levels and enhances emotional well-being. A study found that mindfulness-based stress reduction (MBSR) helped lower cortisol and improved weight loss outcomes in women.
• Yoga: Regular yoga practice reduces stress, enhances flexibility, and promotes mental clarity. A clinical trial demonstrated that yoga-based interventions resulted in a significant reduction in weight and cortisol levels.
• Deep Breathing: Simple deep breathing exercises can help activate the parasympathetic nervous system, reducing stress and promoting relaxation.

Challenges in Making Lifestyle Changes and Their Solutions 

While GLP-1 medications offer significant benefits for weight loss, women may encounter a variety of challenges during their weight loss journey. These challenges can range from side effects to difficulties adhering to lifestyle changes. Understanding these obstacles and implementing effective solutions can significantly enhance the success of GLP-1 therapy.

1. Side Effects: Nausea, Vomiting, and Gastrointestinal Discomfort

One of the most common challenges with GLP-1 medications is gastrointestinal distress, including nausea, vomiting, diarrhoea, and abdominal pain. These side effects occur because GLP-1 medications slow gastric emptying, which helps control hunger but can also lead to digestive discomfort.

In clinical trials, semaglutide has shown that around 30-40% of patients experience nausea during the initial weeks of treatment, with 2-10% reporting vomiting. A study found that 1 in 5 patients discontinued treatment due to side effects, though many cases were mild and resolved over time.

Eating smaller, more frequent meals and avoiding high-fat, greasy foods can help manage nausea. A low-fat diet is also advised as fat can exacerbate gastrointestinal issues. A clinical study on tirzepatide found that following low-fat dietary modifications reduced nausea and improved adherence to the medication regimen.

2. Difficulty Adhering to a Healthy Diet

Maintaining a healthy, balanced diet while undergoing GLP-1 therapy can be difficult, especially for those with busy lifestyles or a history of emotional eating. While GLP-1 medications help curb appetite, adhering to a calorie-controlled, nutrient-dense diet is key for long-term weight loss success. In the STEP 2 trial, patients who adhered to a reduced-calorie diet experienced an average weight loss of 14.9% with semaglutide, compared to a 3.3% loss in the placebo group. However, participants who struggled with diet adherence showed less weight loss, underlining the importance of nutrition.

Importance of Meal Planning and Preparation

Setting realistic dietary goals, planning meals ahead, and incorporating high-protein, fibre-rich foods can improve adherence. Working with a registered dietitian to create personalised meal plans helps ensure that weight loss goals align with nutritional needs. A study showed that meal planning with a focus on protein-rich and low-glycemic index foods significantly enhances weight loss outcomes for those using GLP-1 medications.

3. Challenges with Physical Activity

Exercise is a key component of weight loss, yet many women find it difficult to incorporate regular physical activity into their daily routines. Factors such as fatigue (a common side effect of GLP-1 therapy), lack of time, or low motivation can make it hard to stay consistent with exercise. In the STEP 4 trial, patients who combined semaglutide with regular physical activity (including cardiovascular and strength training exercises) achieved a significantly greater weight loss of 15.1% compared to 5.4% in the placebo group, demonstrating the synergistic effects of exercise and medication.

Gradually Increase in Activity

Start with moderate-intensity activities, such as walking, and gradually progress to more intense strength training and cardiovascular exercises. Building a routine that includes enjoyable activities increases adherence and long-term sustainability. The Diabetes Prevention Program study found that moderate-intensity exercise, such as brisk walking, for 150 minutes per week significantly improved weight loss and metabolic health, especially when combined with dietary changes.

4. Mental and Emotional Barriers

Weight loss journeys are often hindered by psychological challenges such as stress, anxiety, and emotional eating, which can increase the risk of weight re-gain. Women, in particular, may face challenges related to body image, societal pressures, and mood disorders that impact their progress.

A study found that cognitive-behavioural therapy (CBT) was an effective strategy for improving emotional eating and dietary adherence. Women who underwent CBT while using GLP-1 medications had significantly better outcomes in managing stress and weight loss compared to those without psychological support.

Importance of Stress Management and Therapy

Implementing mindfulness techniques, such as deep breathing, yoga, or meditation, can help manage stress. Cognitive-behavioural therapy (CBT) has been shown to reduce emotional eating and improve adherence to both medication and lifestyle changes.

A study on stress and weight loss published in The Journal of Clinical Endocrinology and Metabolism demonstrated that participants who combined CBT with GLP-1 therapy lost significantly more weight and experienced better long-term maintenance compared to those who did not receive mental health support.

5. Weight Regain: How to Prevent It

After achieving initial weight loss with GLP-1 therapy, some women may experience weight regain. This is a common challenge in weight management, especially when GLP-1 medications are discontinued or when lifestyle changes are not maintained.

In the STEP 4 trial, semaglutide showed that weight regain occurred when treatment was paused, with participants gaining back about 2.4 kg on average after discontinuation. This highlights the importance of long-term adherence to medication and lifestyle modifications.

Long-term Adherence

To prevent weight re-gain, continue using GLP-1 medications as prescribed, along with regular follow-ups and ongoing consultation with healthcare professionals to monitor progress. Combining ongoing medication use with sustainable diet and exercise habits is essential for maintaining weight loss. The SUSTAIN trials demonstrated that patients who continued semaglutide over the long term experienced significantly lower rates of weight re-gain compared to those who stopped treatment.

Conclusion

Combining GLP-1 medications with sustainable lifestyle changes is a holistic approach to weight loss that maximises your chances for long-term success. While GLP-1 therapies can curb appetite and support fat loss, it’s the addition of mindful eating, regular physical activity, and mental health strategies that will truly help you maintain the results. The key to success lies in setting realistic goals, tracking your progress, and seeking support when needed. 

Remember, weight loss is a journey, not a race, and every small step you take towards a healthier lifestyle is a step towards a brighter, more energised you. With the right support, patience, and commitment to both your treatment plan and lifestyle changes, you’ll not only lose weight but gain confidence and improved overall well-being. 

If you are looking for personalised guidance, check out details of SheMed weight loss programme here. 

Frequently Asked Questions (FAQs)

1. Can I rely on GLP-1 medications alone for weight loss?

While GLP-1 medications like semaglutide and tirzepatide can significantly support weight loss, they work best when combined with a healthy diet and regular physical activity. These medications help reduce appetite and slow gastric emptying, but lifestyle changes help you maintain a healthy weight and prevent weight regain.

2. Will combining exercise with GLP-1 therapy help me lose more weight?

Yes! Studies have shown that combining exercise with GLP-1 therapy can lead to enhanced weight loss. In the STEP 4 trial, patients who participated in exercise routines alongside semaglutide had greater weight loss results than those on medication alone. Cardiovascular exercises and strength training are particularly effective.

3. What if I experience side effects from GLP-1 medications?

Side effects like nausea and diarrhoea are common when starting GLP-1 therapy but usually subside with time. To reduce side effects, stay hydrated, eat smaller meals, and avoid fatty foods. If symptoms persist, speak to your healthcare provider for tailored advice or to adjust your dosage.

References

1. American Diabetes Association. (2020). The Diabetes Prevention Program (DPP). Diabetes Care, 43(12), 2952-2954. https://pubmed.ncbi.nlm.nih.gov/33068776/
2. Sweeney, G., & Kahn, S. E. (2018). The role of dietary protein in weight management and metabolic health: A review of the evidence. Obesity Reviews, 19(11), 1526-1537. https://pubmed.ncbi.nlm.nih.gov/30060014/
3. Slavin, J. L., & Lloyd, B. (2018). Health benefits of fruits and vegetables. Advances in Nutrition, 9(5), 785-791. https://pubmed.ncbi.nlm.nih.gov/29083823/
4. NHS. (2023). Exercise: How much exercise do you need? NHS. https://www.nhs.uk/live-well/exercise/
5. NHS. (2023). Sleep problems - Every Mind Matters: Tips and advice for better sleep health. NHS. https://www.nhs.uk/every-mind-matters/mental-health-issues/sleep-problems/
6. Khalsa, S. B. S., & Cope, S. (2022). Yoga, mindfulness-based stress reduction and stress-related physiological measures: A meta-analysis. Journal of Behavioral Medicine, 45(1), 1-19. https://pubmed.ncbi.nlm.nih.gov/36904172/
7. NHS. (2023). Stress - Every Mind Matters: Tips and advice for managing stress. NHS. https://www.nhs.uk/every-mind-matters/mental-health-issues/stress/‍
8. Dalle Grave, R., & Calugi, S. (2022). Personalized cognitive-behavioral therapy for obesity (CBT-OB): Theory, strategies and procedures. Cognitive Therapy and Research, 46(2), 123-135. https://pubmed.ncbi.nlm.nih.gov/36904172/