The difference between Mounjaro and Wegovy lies in how they work: Mounjaro mimics two hormones — GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) — creating a dual-action treatment that helps control appetite, improve blood sugar, and boost fat metabolism. Wegovy mimics just GLP-1, helping reduce hunger and increase feelings of fullness.