PMOS (PCOS)
49% reported reduction of irregular menstrual cycles
37% reported reduction of lower abdominal pains
37% reported reduction of hot flushes
Because women's health has waited long enough for research that actually reflects women.
Medical research has historically been designed around male physiology. Women have been underrepresented in clinical trials for decades, leaving significant gaps in how conditions like PMOS, endometriosis and menopause are understood and treated.
This study was designed to change that. Every participant, every data point, and every outcome is female, making it one of the most comprehensive real-world datasets on GLP-1 treatment in women ever collected.
women enrolled across the UK, aged 18 to 79, spanning diverse ethnicities, BMI ranges and health backgrounds.
*This summary presents findings from our recently published research paper, reflecting outcomes observed during the first six months of the study.
average BMI at baseline, spanning Obesity classes I to III. This reflects a real-world patient population, not a cherry-picked trial group.
Retention at six months was over 90%, a notably strong result for GLP-1 treatment delivered outside a hospital or specialist clinic setting.
Metabolic health describes how well your body processes sugars and fats for energy. This study tracked blood sugar, cholesterol and triglycerides to assess changes in women’s metabolic health over six months.
Called HbA1c. One blood test, and it shows your average blood sugar over the past three months - so you can't game it with a good week. It's the test used to diagnose prediabetes and type 2 diabetes.
What happened: most women whose result was in the diabetes range came back into the normal range within six months.
And of the women who started in the normal range, 99.7% stayed there.
LDL is the type of cholesterol that can collect in the walls of your arteries and narrow them over time. That's why it's called "bad" cholesterol, and it's one of the key numbers clinicians look at when assessing your heart health.
Over six months, the study found statistically significant reductions in both LDL and total cholesterol.
Total cholesterol: −0.77
mmol/L average reduction
LDL cholesterol: −0.61
mmol/L average reduction
Triglycerides are fat travelling in your blood - energy from food your body hasn't used yet. They tend to rise alongside weight and blood sugar, which is why they often all go wrong together.
What happened: they fell too, significantly. All three markers moved in the same direction over the same six months.
For the record, and for your GP: triglycerides fell by an average of 0.47 mmol/L.
The weight and the bloods weren't two separate stories. They moved together.
The more weight a woman lost, the further her markers improved - a clear, measurable relationship rather than a coincidence. That's the strongest sign that what changed wasn't just her shape, but how her body was handling sugar and fat.
And 83.1% of women lost at least 10% of their body weight - the threshold associated with meaningful improvement in long-term health.
Each additional 10 kg lost was associated with a further fall of 1.3 mmol/mol in HbA1c and 0.23 mmol/L in total cholesterol.
Our approach is to personalise the dose, guided by each woman’s response to treatment and any side effects. In this study, women achieved meaningful results at an average dose below the licensed maximum.
Average dose exposure across the study sat at around 63% of the maximum licensed dose - and weight loss over six months was comparable to the trajectories reported in the major clinical trials of these treatments.
The study findings support our personalised approach to dosing. Each month, your clinician reviews your progress and any side effects to decide whether to maintain or adjust your dose, tailoring your treatment as your needs change.
This is what personalised actually means, and it's the difference between being treated and being processed.
This describes how our programme approaches care, and the general clinical thinking behind it. It isn't guidance about your own treatment - dosing decisions are always made between you and your clinician. The study did not measure body composition, muscle mass or skin changes.
Side effects with this class of treatment are closely linked to dose, and to how quickly it’s increased. Not racing up the ladder is one of the most practical things that can be done to keep you comfortable.
Losing weight very fast tends to mean losing more than fat alone - muscle goes with it, and that affects how strong you feel and how your body looks as you go.
A steadier, supervised rate of loss is widely considered better for holding on to muscle.
The women in the study got their outcomes at around two-thirds of the maximum. The study highlighted titration guided by your own response matter more than reaching the top the dose quickly.
Dose is the main driver of what this treatment costs. A programme that escalates everyone by default costs you more. One that holds you where you’re doing well doesn’t.
After just six months, women in the study had
already achieved significant weight loss.
10% weight loss is the threshold associated with meaningful health benefit. 83.1% of women passed it.
63.6% of women who started in the highest weight category moved down at least one dress size.
92.1% of those in the category below reached a healthy-range BMI or close to it.
These outcomes came from women managing jobs, families and everything else - not from a controlled trial environment. Average weight loss over six months was comparable to the trajectories reported in the major clinical trials of these treatments, at around two-thirds of the maximum dose.
Our mission is to revolutionise women's health by creating a safe, inclusive space where women of all ages, life stages and socioeconomic backgrounds can access the support they deserve.
At SheMed, we believe every woman deserves personalised, compassionate healthcare, regardless of her circumstances. We recognise that women's health needs and experiences vary, and that too many women have felt overlooked or underserved by traditional healthcare. That's why we've created a platform dedicated to understanding, supporting and advocating for women from all walks of life, making quality healthcare more accessible and inclusive.
*Our research continues beyond weight
Alongside our published study, we reviewed 921 member-reported changes in symptoms associated with PMOS (PCOS), endometriosis, perimenopause and menopause. These results showed...
Testimonials
"It's changed my way of thinking about food. It's taken out the food noise. It's made things quite easy. I can still eat what I want when I want, but I'm not totally consumed by what am I having? What am I eating?"
"One of the things that stood out to me is, you know, you can have access to a clinician. It takes the mental load away. And here we are about a year later and about four stone lighter. I feel like I'm in a really good place now."
"I'm feeling better, certainly moving a lot better. I've recently signed up to go back to dancing. I never thought I would dance again."
"Unlimited messaging meant every question got answered fast. I felt supported the whole way."
From £59 for your first month
Start with a short eligibility check. We'll arrange your blood test, and a clinician will review your results before anything is approved.
Takes two minutes, and it isn't a commitment. Prescription treatment isn't suitable for everyone and is only approved after a clinician reviews your blood tests. Not suitable in pregnancy.