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How to Prepare for Your First Semaglutide Shot
Starting a new medication can feel daunting, especially when it involves self-injections. If you’re about to begin your journey with semaglutide, it’s completely normal to have a mix of excitement and apprehension. Semaglutide has emerged as a valuable tool in weight management, helping many people achieve their health goals and improve their quality of life. However, the thought of giving yourself an injection can stir up anxiety and uncertainty. It’s important to remember that you’re not alone in feeling this way. Many individuals share these feelings when beginning treatment, and there are strategies to help ease the transition. Preparing for your first semaglutide shot involves not just understanding the practical steps, but also nurturing your emotional well-being. In this blog, we will guide you through the preparation process, from selecting the right location to managing potential side effects. Our goal is to help you feel more confident and informed, making your first injection a positive step forward in your weight management journey. You are taking an important step toward better health, and with the right preparation, you can approach this new experience with assurance and peace of mind.
Understanding the Injection Process
If you're starting a weight loss programme with pens like Wegovy or Mounjaro, understanding how they work and how to prepare for your first injection is key. Both pens function similarly by mimicking natural hormones to regulate appetite and blood sugar, supporting significant weight loss over time.
Understand Your Dose:
- Wegovy typically starts at 0.25mg weekly, gradually increasing to 2.4mg over several months.
- Mounjaro doses begin at 2.5mg weekly and may increase based on your healthcare provider's recommendation.
Review Instructions
Carefully read the leaflet provided with the pen and watch any instructional videos to understand proper injection techniques.
Types of Semaglutide Delivery Devices
Semaglutide can be administered through various delivery devices, primarily pens and pre-filled syringes. Understanding these devices is crucial for effective self-administration.
- Pen Devices: The most common method for self-injection is the pen device, which comes pre-filled with semaglutide. The device is user-friendly and designed for easy injection. Each pen can deliver multiple doses, depending on the specific product. In a clinical study published in the New England Journal of Medicine, patients preferred using pen devices over traditional syringes due to their ease of use and convenience, with over 80% reporting higher satisfaction.
- Pre-Filled Syringes: Although less common, pre-filled syringes are another option for administering semaglutide. These syringes contain a single dose of the medication. While they require careful handling, they can be used in both clinical settings and at home.
Basic Steps for Administering the Injection
Knowing the correct procedure for administering semaglutide is crucial for a successful experience. Here are the essential steps involved:
Selecting an Injection Site:
- The most recommended sites for injecting semaglutide are the abdomen, thigh, and upper arm.
- For the abdomen, choose a spot at least two inches away from the belly button.
- The outer thigh is ideal, and the back of the upper arm can also be used.
- It’s important to rotate the injection sites with each dose to prevent local reactions and lipodystrophy (changes in fat tissue)
Cleaning the Injection Site:
- Before injecting, clean the selected site thoroughly with an alcohol swab. This reduces the risk of infection and ensures a hygienic injection. A study indicated that proper site cleaning reduces infection risk by up to 50%.
Inserting the Needle and Injecting the Medication:
- Pinch the skin around the chosen injection site.
- Insert the needle at a 90-degree angle for the abdomen and thigh, or at a 45-degree angle for the upper arm.
- Inject the medication by pressing the button on the pen or pushing the plunger on the syringe. Clinical guidelines suggest that a slow and steady injection minimises discomfort and allows for better absorption.
Disposing of the Needle and Pen Safely:
- After the injection, carefully remove the needle and dispose of it in a sharps container. If you use a pen, ensure the needle is disposed of properly after each use. The importance of safe disposal is emphasised by the CDC, which states that improper disposal can pose health risks to others.
Preparing for Your First Injection
Choose a Comfortable Location
The setting where you administer your injection can greatly influence your comfort level. Here are some tips:
- Select a Quiet and Well-Lit Space: Find an area where you can focus without distractions. Good lighting is essential to see what you're doing clearly.
- Gather Necessary Supplies: Before starting, ensure you have all required items within reach, including the semaglutide pen, alcohol swabs, and a sharps container. Being organised can reduce anxiety and make the process smoother.
Relaxation Techniques
Feeling anxious about the injection is normal. Here are a few relaxation techniques that can help:
- Deep Breathing: Take a few moments to practise deep breathing exercises. Inhale slowly through your nose, hold for a few seconds, then exhale through your mouth. Studies have shown that deep breathing can lower anxiety levels and promote relaxation.
- Meditation: Consider incorporating mindfulness or meditation practices before your shot. Using guided meditation apps or calming music can help set a peaceful atmosphere.
First-Time Tips
- Watch Instructional Videos: Visualising the injection process through instructional videos can increase your confidence. Many healthcare providers offer resources or links to reliable sources. Research indicates that patients who watch instructional videos report feeling more prepared and less anxious about self-injections.
- Practice on a Soft Surface: If you are particularly anxious, practising the motion of the injection on a soft surface can help familiarise you with the technique without the pressure of actually injecting yourself.
- Seek Support: Do not hesitate to ask for help from your healthcare provider, family, or friends. Support groups, whether in-person or online, can provide valuable encouragement and tips from others who are also using semaglutide.
Managing Potential Side Effects
As with any medication, semaglutide may cause side effects. Being aware and proactive can help mitigate these challenges.
Common Side Effects
Some of the most frequently reported side effects of semaglutide include:
- Nausea: A common side effect, especially during the initial weeks of treatment. Clinical trials indicated that approximately 30% of participants experienced nausea . This typically lessens over time.
- Vomiting: Less common but can occur, particularly during the early stages of treatment.
- Diarrhoea and Constipation: Gastrointestinal symptoms may vary among individuals, so it’s essential to monitor your body’s responses.
- Appetite Changes: Many users report a decrease in appetite, which can aid in weight loss. In a study, 62% of participants noted reduced hunger levels after starting semaglutide.
Conclusion
Preparing for your first semaglutide injection is a critical step toward a successful experience and positive outcomes in your weight management journey. By understanding the injection process, selecting a comfortable environment, utilising relaxation techniques, and being aware of potential side effects, you can approach this new chapter with confidence. Remember that this journey is about progress, and it’s entirely normal to seek help along the way. Whether from healthcare professionals, friends, or support groups, building a network of support can make all the difference. Proper preparation and a proactive mindset are your best allies in navigating the challenges of semaglutide treatment. By following these strategies, you can set the stage for a successful experience and embrace the benefits of semaglutide in your weight loss journey.
References
- LeRouge, C., & Ma, J. (2023). GLP-1 receptor agonist semaglutide for weight loss in adults with obesity: A systematic review and meta-analysis of randomized controlled trials. https://pubmed.ncbi.nlm.nih.gov/37879878/
- Ghosh, A., & MacKenzie, L. T. (2021). Semaglutide for the management of obesity: A review of its efficacy and safety. https://pmc.ncbi.nlm.nih.gov/articles/PMC8294388/
- Dawood, R., Ismail, B., Alshaikh, A., & Alomar, A. (2021). The effects of GLP-1 receptor agonists on weight loss and body composition in patients with type 2 diabetes https://pmc.ncbi.nlm.nih.gov/articles/PMC8169358/
- Liu, Y., & Liu, Y. (2020). Efficacy and safety of semaglutide for the treatment of obesity: A systematic review and meta-analysis. https://pmc.ncbi.nlm.nih.gov/articles/PMC7887535/
- Koh, S. J., Lee, Y. S., & Kim, S. K. (2022). Clinical efficacy and safety of semaglutide in the treatment of obesity https://pmc.ncbi.nlm.nih.gov/articles/PMC9545130/
- Möhlmann, C., & Möller, K. (1998). The role of GLP-1 in the regulation of insulin secretion and appetite. Diabetologia, 41(4), 307-313. https://pubmed.ncbi.nlm.nih.gov/9663633/
- Sweeney, G., & Karason, K. (2016). GLP-1 receptor agonists: A new therapeutic approach for the treatment of obesity https://pmc.ncbi.nlm.nih.gov/articles/PMC5101544/
- Bashir, M. N., Boogerd, C. J., & Stolk, R. P. (2023). The safety and efficacy of semaglutide in patients with obesity: A systematic review and meta-analysis https://pmc.ncbi.nlm.nih.gov/articles/PMC10570228/
- Rosenstock, J., & Ghosh, A. (2020). Semaglutide: A review of its pharmacology and clinical applications in diabetes and obesity. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK603723/
- Kizilbash, F., & Kwan, C. (2023). Efficacy and safety of semaglutide in the management of obesity: A systematic review and network meta-analysis. https://pmc.ncbi.nlm.nih.gov/articles/PMC10748770/
Mounjaro is a new medication developed by Eli Lilly that contains the active ingredient tirzepatide. It was originally designed to help people with type 2 diabetes manage their blood sugar levels. Mounjaro is administered as a once-weekly injection using a self-injection pen, typically into the abdomen, thigh, or upper arm. In the UK, tirzepatide (Mounjaro) has been approved for use by the Medicines and Healthcare products Regulatory Agency (MHRA).
Besides helping with blood sugar, Mounjaro has also been found to be very effective at helping people lose weight. This is why you might have heard it called a "weight loss jab" in the media.
- How you take it: You inject Mounjaro once a week. Your doctor will usually start you on a small dose and slowly increase it over time. This helps your body get used to the medicine and can lower the chance of you feeling sick.
How it Works:
Mounjaro is like a "twin hormone" medicine. It acts like two natural gut hormones, GLP-1 and GIP. These hormones help control blood sugar and appetite.
- It helps your body release more insulin when needed and lowers sugar from your liver, improving blood sugar control.
- It makes you feel fuller sooner and for longer, helping you eat less.
- Working on both GLP-1 and GIP is thought to be why it can lead to greater weight loss than medicines that only use GLP-1 (like Semaglutide in Ozempic/Wegovy).
What is it Used For?
- Type 2 Diabetes: Mounjaro lowers blood sugar effectively, often helping patients reach better levels (lower HbA1c). It's used alongside diet and exercise, sometimes with other diabetes medicines, typically when standard treatments aren't enough, especially if weight loss would help.
- Weight Management: In studies, people using Mounjaro lost a significant amount of weight, often averaging 15-20% of their body weight over about 1 to 1.5 years. It's approved for adults with obesity (high BMI) or those with a lower BMI and a weight-related health problem.
Access in the UK:
- NHS: Mounjaro is available on the NHS for type 2 diabetes if you meet certain criteria. For weight loss, NHS access is starting gradually through specialist clinics for adults with a very high BMI and multiple weight related health issues.
- Private: You can also access Mounjaro privately through weight loss clinics, pharmacies or online services like ours if you meet the medical criteria. SheMed operates a weight management programme specifically tailored for women, which includes the potential prescription of GLP-1 medications such as Mounjaro and Wegovy, provided the individual meets their medical criteria.
Mounjaro vs. Semaglutide (Ozempic/Wegovy):
Both are effective weekly injections. Semaglutide works on GLP-1 while Mounjaro works on both GLP-1 and GIP. Studies suggest Mounjaro may lead to slightly more weight loss on average. But choice of drug depends on a number of factors and is very individual.
Side Effects and Safety:
Common side effects are usually mild stomach issues (nausea, vomiting, etc.) that often improve over time. Because it affects appetite, you'll feel less hungry. If you take other diabetes medicines, your doctor might adjust doses to prevent low blood sugar.
Serious side effects are rare, but contact a doctor immediately for severe tummy pain, persistent vomiting, allergic reactions, or worrying mood changes.
Important Note: Mounjaro works best with healthy eating and exercise. If you stop Mounjaro, appetite and weight can return if lifestyle changes aren't maintained.
Check our healthcare support page to see if Mounjaro could be a suitable option for you based on your health needs and the latest criteria.
FAQs
1. How is Mounjaro administered?
Mounjaro is given as a once-weekly injection. Your healthcare provider will guide you on the correct dosage and administration technique.
2. Can I use Mounjaro if I’m pregnant or breastfeeding?
No, tirzepatide is not recommended during pregnancy or breastfeeding, as its safety in these situations has not been established. If you are planning to conceive or are breastfeeding, discuss alternative options with your doctor.
3. How long does it take to see results with Mounjaro?
While individual results vary, many users begin noticing changes within a few weeks. Maximum benefits are typically observed after several months of consistent use, alongside dietary and lifestyle adjustments.
References
- MotherToBaby. (2024). Tirzepatide (Mounjaro®, Zepbound®) - Mother To Baby | Fact Sheets. https://www.ncbi.nlm.nih.gov/books/NBK605070/
- Watanabe, M., & Hasegawa, Y. (2021). Tirzepatide in adults with obesity and type 2 diabetes. New England Journal of Medicine, 385(11), 1046-1056. https://doi.org/10.1056/NEJMoa2107519
- Kahn, S. E., & Florez, J. C. (2023). Tirzepatide: A dual GLP-1 and GIP receptor agonist for type 2 diabetes management. PMC, 11543192. https://pmc.ncbi.nlm.nih.gov/articles/PMC11543192/
- Kahn, S. E., & Florez, J. C. (2023). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine. https://pubmed.ncbi.nlm.nih.gov/36751934/
- Nauck, M. A., & Quast, D. R. (2020). Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide: A review of their roles in obesity and type 2 diabetes. Endocrine Reviews, 41(3), 1-24. https://pubmed.ncbi.nlm.nih.gov/32459834/
- Kahn, S. E., & Florez, J. C. (2020). Tirzepatide: A novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist for type 2 diabetes management. Endocrine Society. https://www.ncbi.nlm.nih.gov/books/NBK605070/
A groundbreaking clinical trial has revealed that Mounjaro (tirzepatide) leads to greater weight loss than its rival Wegovy (semaglutide), offering new hope for people struggling with obesity.
Head-to-Head Results: Mounjaro vs Wegovy
The study, presented at the European Congress on Obesity and published in the New England Journal of Medicine, compared the two most talked-about weight-loss injections. Over 72 weeks, participants taking Mounjaro lost an average of 20% of their body weight, compared to 14% for those on Wegovy. That’s a significant difference, especially for those with a lot of weight to lose.
Key Findings:
- 32% of Mounjaro users lost at least a quarter of their body weight, compared to 16% on Wegovy.
- Waistlines shrank more: Mounjaro users lost an average of 18cm from their waists, while Wegovy users lost 13cm.
- Health improvements: Mounjaro also led to better blood pressure, blood sugar, and cholesterol results.
- Similar side-effect profiles for both drugs.
- Women tended to lose more weight than men on both medications.
How Do These Medications Work?
Both Mounjaro and Wegovy help people feel full, reducing appetite and encouraging the body to burn stored fat. The key difference is that Wegovy mimics one appetite-control hormone, while Mounjaro targets two, which may explain its superior results.
Mounjaro and Wegovy: Availability and Eligibility in the UK
Both Mounjaro and Wegovy are available for weight management in the UK through both the NHS and private clinics. Here’s what you need to know about who can access them and how.
NHS Eligibility Criteria
Both medications are available on the NHS, but only for people who meet specific criteria:
- Adults with a BMI of 35 or above and at least one weight-related health condition (such as high blood pressure, cardiovascular disease, or osteoarthritis).
- Adults with a BMI of 30 or above who qualify for referral to a Specialist Weight Management Service (SWMS) and have not succeeded with other weight loss methods.
- Some groups, such as certain minority ethnic backgrounds or those with cardiovascular disease, may qualify with a BMI as low as 27.5.
Private Prescription Criteria
For those seeking treatment privately, the requirements are less strict:
- BMI of 30 or above, or BMI of 27 or above with a weight-related health condition or from certain ethnic backgrounds.
- Patients must complete an online or in-person consultation, including questions on weight, medical history, and current medications.
- New regulations require verification of identity and medical suitability, often with GP input or supporting records.
Estimated Monthly Costs
Customers seeking access to weight loss treatments like Mounjaro and Wegovy can conveniently receive private prescriptions through online clinics such as SheMed Healthcare. SheMed specializes in providing healthcare services tailored for women, including a dedicated weight loss programme.
Here is a breakdown of the programme's pricing:
- Starting Price: £99 for the initial dose.
- Includes: This initial cost covers a health screening, which involves a blood test to ensure the treatment is safe and appropriate.
- Subsequent Doses: Later doses are priced at £159 each.
Conclusion
This major trial confirms Mounjaro's significant edge over Wegovy, demonstrating superior weight loss and better health outcomes for individuals with obesity. Both medications represent powerful advancements in weight management and are available in the UK via NHS and private pathways, offering promising new options for those seeking effective medical treatment. If you have any questions about these medications or weight loss options, please visit the SheMed Support website for more information.