Are you navigating a weight loss journey with GLP-1 medications like Wegovy or Mounjaro? While these drugs can be life-changing in helping manage weight, they also come with unique challenges that aren’t always discussed. Rapid weight loss and the way these medications affect digestion can increase the risk of deficiencies in essential micronutrients such as vitamin B12, iron, and calcium. These nutrients are vital for energy, immunity, bone health, and overall well-being. Yet, without proper attention, they can easily be overlooked, leaving women vulnerable to fatigue, weakened immunity, or even long-term health issues.
For women in the UK, where busy lifestyles and cultural food habits might already impact nutrient intake, addressing these potential deficiencies is even more critical. The good news? With the right knowledge and practical strategies, it’s entirely possible to protect your health while achieving your weight loss goals. This guide will shed light on the micronutrients that matter most, why they are at risk during GLP-1 treatment, and how to optimise your intake to stay healthy, energetic, and strong. Whether you’re just starting with GLP-1 drugs or are well into your weight loss journey, this information will empower you to make choices that support both your short-term goals and long-term health.
GLP-1 receptor agonists mimic the action of the natural GLP-1 hormone, which is secreted in the gut in response to food intake. This hormone plays a critical role in appetite regulation and metabolic processes. Here's how:
The impact of GLP-1 drugs on weight loss is well-documented through robust clinical trials.
The benefits of GLP-1 drugs are amplified when combined with healthy lifestyle choices. For example, pairing these medications with a high-fibre diet, regular exercise, and mindful eating practices creates a holistic weight loss strategy.
As evidenced by clinical studies and patient success stories, GLP-1 drugs are not just weight loss aids; they represent a new frontier in sustainable weight management. By targeting the body's natural satiety and hunger mechanisms, these medications empower individuals to achieve and maintain significant weight loss while improving their overall health.
Micronutrients—vitamins and minerals required in small amounts—are critical for maintaining overall health and well-being. Despite their “micro” designation, these nutrients play a “macro” role in various bodily functions, including energy production, immune defense, and maintaining structural integrity. Inadequate intake or poor absorption of micronutrients can lead to deficiencies that negatively impact health, particularly in individuals undergoing significant dietary or medical interventions.
Micronutrients support critical physiological processes, including:
Vitamin B12 is essential for red blood cell formation, DNA synthesis, and nervous system function.
Iron supports oxygen transport in the blood, brain function, and immune health.
Micronutrients are indispensable for maintaining good health, yet deficiencies are surprisingly common, particularly among individuals with restricted diets or medical conditions. By adopting practical strategies such as dietary adjustments, supplementation, and regular monitoring, it is possible to maintain optimal micronutrient levels. Let’s explore actionable steps supported by scientific evidence to help optimize micronutrient intake and absorption.
A well-rounded diet remains the cornerstone of good nutrition.
Supplements can fill nutritional gaps, especially for individuals at high risk of deficiency.
Routine blood tests are essential for assessing and maintaining micronutrient levels.
Partnering with a healthcare provider ensures personalised and effective strategies.
Losing weight with GLP-1 medications is a significant milestone in reclaiming health and confidence, but it comes with responsibilities to safeguard overall wellness. Micronutrient deficiencies can silently undermine the progress made through weight loss, leading to fatigue, poor immunity, or brittle bones if not addressed. By being mindful of nutrient intake, prioritising foods rich in essential vitamins and minerals, and considering supplements when necessary, women in the UK can stay ahead of potential health pitfalls.
Think of your health as a delicate balance. While weight loss is a key component, maintaining proper nutrition ensures that your body remains resilient, vibrant, and prepared for whatever challenges life throws your way. Through regular monitoring, consultation with healthcare providers, and small but impactful dietary adjustments, it’s possible to achieve weight loss without compromising on overall health.
This journey is not just about seeing changes on the scales but also about feeling stronger, healthier, and more capable in everyday life. Let your weight loss transformation be a holistic one—fuelled by both the physical progress and the inner vitality that comes from proper nourishment. Every step you take towards addressing these considerations today is an investment in your long-term health and happiness.
Rapid weight loss and the effects of GLP-1 medications on digestion can reduce the absorption of key nutrients like vitamin B12, iron, and calcium. Micronutrient deficiencies can lead to fatigue, weakened immunity, and poor bone health, making it essential to monitor and optimise your intake.
Common deficiencies include:
Here are some strategies:
Supplements can help, especially if blood tests reveal deficiencies. For example:
Always consult your GP or a dietitian before starting supplements.
Regular blood tests every 3-6 months are recommended to track levels of vitamin B12, iron, calcium, and vitamin D. If deficiencies are detected, your GP may recommend more frequent testing or dietary adjustments.
While no food groups need to be entirely avoided, consider these tips:
Yes, fortified foods are an excellent way to boost nutrient intake. Examples include:
If you notice symptoms such as fatigue, brittle nails, or hair loss, consult your GP. They may recommend a blood test to confirm deficiencies and provide tailored advice on dietary or supplemental solutions.
A new weight loss programme is gaining significant traction across the UK, drawing more than 16,000 women in just two months. SheMed, a digital health provider, is reshaping how women approach weight management by integrating scientific precision with a patient-first philosophy.
Unlike conventional dieting plans, SheMed’s approach is designed specifically for women’s unique metabolic and hormonal profiles. The programme, which includes a GLP-1-based medical intervention, aims to promote sustainable weight loss without extreme dieting or unrealistic exercise regimens.
“We understand that women’s bodies work differently, and our programme is tailored to reflect that,” said Olivia Ferro, co-founder & CEO of SheMed. “This isn’t just about weight loss—it’s about long-term health, confidence, and a fundamentally different approach to well-being.”
A Medical-Grade Approach to Weight Loss
SheMed differentiates itself by offering a medically supervised weight loss programme that combines prescription GLP-1 medications with private GP oversight. The programme’s core principles include:
Uncovering Hidden Health Risks
As part of its commitment to responsible prescribing, SheMed introduced a mandatory blood test requirement for all patients before administering GLP-1 medications. The results of this initiative were striking: 99% of applicants exhibited health conditions, including high cholesterol, fatty liver, and early-stage diabetes.
Initially launched as a clinical study, the blood test requirement has now been made permanent. “This initiative has fundamentally changed how we assess weight loss patients,” said Chloe Ferro, SheMed’s co-founder and Chief Growth Officer. “Many women seeking weight loss treatment had underlying health conditions they weren’t aware of. Early detection is key to improving long-term health outcomes.”
The General Pharmaceutical Council (GPhC) has recently tightened regulations around online prescriptions for obesity medications. SheMed’s rigorous screening process places it ahead of industry standards, ensuring that only patients meeting strict medical criteria receive treatment. The company’s fixed pricing model—£159 every four weeks, with no cost increase as medication doses adjust—further differentiates it in a market where pricing structures often fluctuate unpredictably.
Regulatory Scrutiny and Industry Implications
SheMed’s stringent protocols come at a time of heightened regulatory scrutiny over the distribution of GLP-1 medications in the UK. With the rise in popularity of these drugs, regulators have moved to curb inappropriate prescribing practices. Unlike some providers, SheMed does not base eligibility solely on weight or BMI. Instead, its screening process considers broader health indicators, ensuring treatment aligns with patient safety guidelines.
“We’re not just another online pharmacy dispensing GLP-1s,” said Olivia Ferro. “We’re setting new standards for what responsible prescribing should look like.”
As the UK continues to grapple with rising obesity rates and evolving treatment protocols, SheMed’s approach offers a glimpse into the future of medically integrated digital health solutions. With a growing patient base and increasing regulatory backing for stricter prescribing practices, the company is positioned as a leader in the next phase of weight loss care.
For more information, visit www.shemed.co.uk.
Finding the right dosage for any medication is essential, as everyone responds differently. This is equally true for GLP-1 medications. Our clinical team will work closely with you to determine the most suitable dose, balancing the desired effects with any side effects you may experience.
Mounjaro, for example, has three stable treatment doses: 5mg, 10mg, and 15mg. Additionally, there are intermediary doses of 2.5mg, 7.5mg, and 12.5mg, which help transition between these stable doses.
In practice, this means that treatment with Mounjaro will typically begin at 2.5mg per week for the first four weeks. If you tolerate this well and experience no significant side effects, we will generally increase the dose to 5mg from the second month. However, if you do experience side effects, we may keep you on 2.5mg for a longer period to allow your body time to adjust before increasing the dose.
Once you reach 5mg, we will usually maintain this dose for a few months unless your weight loss progress is minimal. While progress varies between individuals, a useful benchmark is a minimum weight loss of approximately 1% of your starting weight per month.
If you continue to make good progress at 5mg, we may agree that there is no need to increase the dose further. You can remain on this dose for as long as necessary. However, if progress slows, we may increase the dose to 7.5mg for a month or two before stepping up to the next stable dose of 10mg.
At this stage, we would typically maintain the 10mg dose for a few months. Together, we will keep an eye on your progress and decide whether to continue at this level or increase to the maximum dose if necessary.
Our goal is gradual and sustainable weight loss. GLP-1 treatment is not a "quick fix" but rather a long-term approach to improving your health and maintaining a healthy weight.
What happens when I reach my goal weight?
Once you achieve your target, we will work with you to determine the most appropriate dose to maintain your weight. For some, this will be the current dose, while others may step down to the next stable dose. Our clinical team will closely monitor your progress and help you find the right dosage to maintain a healthy weight and overall well-being.
Dr Matthew Noble
SheMed, a pioneering women’s health company, has announced an extension to its ground-breaking GLP-1 clinical trial in response to an extraordinary level of interest. The entry period, which was initially scheduled to conclude by December 2024, will now run until January 31, 2025.
Co-founders Chloe and Olivia Ferro are determined to create a safer, evidence-based digital health system that prioritises the well-being of women. This extension supports their mission to address long-standing gaps in women’s healthcare research and treatment.
The SheMed Weight Loss Programme, a comprehensive initiative that combines weight loss support with advanced clinical research, aims to conduct the largest clinical study of UK women for GLP-1 medications to date. Historically used to treat diabetes and obesity, GLP-1 medications have untapped potential in addressing broader women’s health conditions. SheMed’s study seeks to uncover definitive evidence and actionable insights on how these medications can benefit women beyond weight management.
Through this programme, SheMed is collecting data that could revolutionise care for conditions such as Polycystic Ovary Syndrome (PCOS) and menopause. By doing so, the study hopes to not only empower women to achieve their health goals but also pave the way for significant advancements in the field of women’s health—a domain that has historically lagged behind other medical research areas.
The SheMed Weight Loss Programme is designed as a high-adherence care model, ensuring participants stay on track and achieve their health goals safely. Key programme features include:
The programme’s rigorous approach not only promotes individual success but also ensures the reliability of SheMed’s clinical findings.
To maintain the highest research standards, SheMed has implemented strict acceptance criteria for the clinical trial. Eligible participants must:
The trial will be one of the most comprehensive studies ever conducted in the UK for GLP-1 medications.
Participants will benefit from:
Due to overwhelming demand, SheMed has extended the trial’s duration to accommodate more participants while maintaining its rigorous standards. This extension allows SheMed to continue its mission of empowering women through evidence-based healthcare and contribute meaningful data to the medical community.
Participant Benefits
Participants will gain access to a wealth of support and resources, including:
Data Privacy
SheMed is committed to protecting participants’ personal information. All data collected is anonymised and used solely for research purposes. SheMed does not sell or share any data with third parties.
Study Timeline
Join the SheMed Clinical Trial
This extended timeline offers a unique opportunity for eligible participants to contribute to one of the largest women’s health studies in the UK. By joining the SheMed Weight Loss Programme, participants are not only investing in their health but also shaping the future of women’s healthcare.
Interested individuals can visit SheMed’s website to learn more about the programme and apply to join this landmark clinical study. With strict acceptance guidelines in place and limited slots available, early application is highly encouraged.
Sign up and check your eligibility today: https://www.shemed.co.uk/clinical-study
We have learnt many skills over the past few weeks and it's important that we consolidate all that we have learnt over the past few weeks to ensure you are armed and ready to keep up the good work you've already achieved. As time ticks on, progress may start to slow but it’s important that you maintain motivation and keep yourself focused on your overarching goals.
Whilst weight loss is part of this, the number on the scale is not the only thing we should be focused on. This journey is about developing sustainable habits that allow you to increase your confidence, improve your health and wellbeing, and live your life to the fullest. No matter what your goal, hold this close as you move forward on your weight management journey to maintain success.
Thinking about what we have learned over the past 10 weeks, here is a breakdown of tips and tricks to keep you focused on your goals and maintain the weight you've lost that is allowing you to live life to the fullest.
1. Practise Mindful Eating:
Keep distractions to a minimum during meals and snacks. Even if you’re rushed off your feet or eating on the go, give yourself time to savour each bite as a small act of self-care that will leave you feeling satiated and energised for the rest of your day1.
2. Keep Your Nutrition Balanced:
Enjoy a diverse and nutrient-packed diet by including whole grains (e.g. brown rice or pasta, quinoa, oats), lean proteins (e.g. chicken, white fish, greek yoghurt, tofu), fruits (e.g. berries, kiwis, apples), and vegetables (e.g. spinach, broccoli, cauliflower) in satisfying portions. Avoid restrictive eating to prevent resentment and the potential for overeating later on2.
3. Find Enjoyable Exercise:
Find activities you enjoy to make exercise a sustainable part of your routine. This doesn’t have to be a killer workout at the gym. Simple things like gardening, walking the dog, playing with your kids, dancing round the house are just as good! The key here is enjoyment, engaging in something that makes you feel good and energised3.
4. Get a Good Nights Rest:
Prioritise your sleep to ensure you optimise your wellbeing and regulate hunger hormones. Keep your phone on silent, get outside during sunrise and sunset, and practise relaxing activities like mindfulness to get your body ready for sleep4.
5. Keep Stress to a Minimum:
Life brings inevitable stress, making avoidance challenging. Implementing stress-management techniques like meditation, deep breathing, or yoga can reduce reliance on negative coping mechanisms, fostering calmness and readiness for life's challenges5
6. Stay Hydrated:
The first step of breaking down both dietary and stored fat is called hydrolysis, a process that requires water. Therefore, drinking enough water is required to burn fat, and it helps us stay on form during workouts by ensuring our muscles can contract properly to avoid cramp and fatigue6.
7. Stay Realistic and Accountable:
Set goals that align with your lifestyle, but make sure you are compassionate and adjust things if you need to. This process is all about finding what fits into your lifestyle, not forcing yourself to do things that aren’t achievable long term. The only way you will maintain new behaviours is by making them accessible and enjoyable!
8. Reach Out for Support:
You might have bad days, and that is more than okay! This journey is going to be challenging as you unpick behaviours that have become your norm. Whether you reach out to supportive friends and family or find support in groups with people experiencing similar things - remember, together anything is possible.
Embarking on a journey of weight maintenance is a commitment to long-term well-being. By incorporating these tips into your daily life, you'll not only achieve a healthy weight but also cultivate habits that will support your overall health and vitality. Remember, it's the small, consistent changes that lead to lasting success and you have access to our content at all times.
Activity: Wellbeing Habit Bingo!
Download our Wellbeing Habit Bingo card (or create your own!) to track your wellbeing activities. Simply cross out a behaviour when you complete it, then when you have completed a line or the grid (it’s your choice), treat yourself to something nice like a bunch of flowers, a new gadget, or a day out! This way you will stay motivated and keep yourself happy!
References:
As you revisit your goals from week 1, think about what has been achieved in the first 10 weeks and what requires further effort. When you are setting new goals, consider a mix of short and long-term objectives, extending beyond the number on the scale. While numerical goals are practical, acknowledge the broader impact on your health, exercise, confidence, social life, and more. Your weight loss journey is so much more than simply weight loss, so it’s important you shift your focus beyond food and weight, recognising the holistic improvements in your life.
Often, celebrations can involve fancy food or alcohol which may impact your progress. Whilst it is important to ensure you don’t restrict the foods that you enjoy to avoid bingeing, it’s also important to consume them in moderation to avoid weight gain. To avoid the emotional aspect of food which can lead to overconsumption, think of ways to celebrate your successes in ways that don’t involve food and alcohol to keep yourself motivated whilst sustaining your success.
With that in mind, let’s consider non-food-related celebrations to detach from emotional eating, sustaining your weight loss efforts so you can keep up the excellent work!
1. Get Some New Workout Gear:
Treat yourself to a new set of workout clothes or shoes as a reward for your hard work.
2. Plan a Spa Day:
Schedule a relaxing spa day or a massage to pamper yourself and unwind.
3. Buy Yourself a New Outfit:
Update your wardrobe with a clothing item that makes you feel confident and stylish. Make sure you buy new clothes as you lose weight, rather than waiting until you achieve your weight loss goal, as this will keep you feeling good on your journey!
4. Create a Vision Board:
Visualising your goals can help them feel more achievable and realistic. Get creative and enjoy an evening of crafts and goal setting for the future you.
5. Plan an Activity:
Consider an activity that was previously out of reach and make plans to engage in it. Your weight loss journey not only enhances your health but also unlocks opportunities for activities that were once inaccessible.
6. Organise a Weekend Away:
For a bigger milestone, consider treating yourself to a weekend away to recharge after your hard work and celebrate your success!
Activity: Create a Vision Board
Download our Create a Vision Board Worksheet to put your goals down on paper! This is a creative activity that will allow you to visualise your goals and remind you why you are embarking on this journey even on the hardest of days.
By reaching this point you are achieving incredible things and should be proud of what you’ve achieved so far. At SheMed, we are elated that you are succeeding on your weight loss journey and continue to work alongside us. Don’t stop here, keep up that motivation by recognising what you’ve achieved so far and pushing yourself forward to further health and wellbeing for your future self.